A.M.S. Mayer, Ph.D.
Professor of Pharmacology

Department of Pharmacology
Chicago College of Osteopathic Medicine
Midwestern University
555 31st Street
Downers Grove, IL 60515

 

Phone: (630) 515-6951
Fax: (630) 515-6295
E-mail: amayer@midwestern.edu

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MARINE PHARMACEUTICALS:
THE PRECLINICAL PIPELINE

During the period 1998-2013, the global marine pharmaceutical preclinical pipeline involved research with more than 1,000 marine chemicals which demonstrated antibacterial, anticoagulant, anti-inflammatory, antifungal, anthelmintic, antiplatelet, antiprotozoal, and antiviral activities; actions on the cardiovascular, endocrine, immune, and nervous systems; and other miscellaneous mechanisms of action. The marine pharmaceutical preclinical pipeline is systematically reviewed in the following 16 peer-reviewed articles:,

16. Mayer, A.M.S., A.D. Rodriguez, Orazio Taglialatela-Scafati and N. Fusetani. Marine pharmacology in 2012-2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; affecting the Immune and Nervous System, and other Miscellaneous Mechanisms of Action. MARINE DRUGS (accepted for publication 8/20/2017).
15. Mayer, A.M.S., A.D. Rodriguez, Orazio Taglialatela-Scafati and N. Fusetani. Marine pharmacology in 2009-11: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; affecting the Immune and Nervous System, and other Miscellaneous Mechanisms of Action. MARINE DRUGS 11:2510-2573, 2013. Published July 16, 2013 and available at http://www.mdpi.com/1660-3397/11/7/2510
14. Mayer, A.M.S., A.D. Rodriguez, R. Berlinck and N. Fusetani.  Marine pharmacology in 2007-8:  Marine Compounds with Antibacterial, Anticoagulant, Antifungal, Anti-inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; affecting the Immune and Nervous System, and other Miscellaneous Mechanisms of Action. Comparative Biochemistry and Physiology Part C: 153: 191-222, 2011. 
13. K.B. Glaser and Mayer, A.M.S. A Renaissance in Marine Pharmacology: From Preclinical Curiosity to Clinical Reality. Biochemical Pharmacology 78: 440-448, 2009.
12. Mayer, A.M.S., A.D. Rodriguez, R. Berlinck and M.T. Hamann.  Marine pharmacology in 2005-6:  Marine Compounds with Antibacterial, Anticoagulant, Antifungal, Anthelmitic, Anti-inflammatory, Antiprotozoal, and Antiviral Activities; affecting the Cardiovascular, Endocrine, Immune and Nervous Systems and other Miscellaneous Mechanisms of Action. Biochimica et Biophysica Acta, General Subjects, 1790: 283-308, 2009
11. Mayer, A.M.S. and K. R. Gustafson.  Marine Pharmacology in 2005-6: Antitumor and Cytotoxic    Compounds. European  Journal of Cancer 44:2357-2387, 2008.
10. Mayer, A.M.S., A.D. Rodriguez, R. Berlinck and M. T. Hamann. Marine pharmacology in 2003-4: Marine Compounds with Anthelminthic, Antibacterial, Anticoagulant, Antifungal, Anti-inflammatory, Antimalarial, Antiplatelet, Antiprotozoal, Antituberculosis, and Antiviral Activities;  affecting the Cardiovascular, Immune and Nervous Systems and other Miscellaneous Mechanisms of Action. Comparative Biochemistry and Physiology Part C: 145: 553-581, 2007
9. Mayer, A.M.S. and K. R. Gustafson, Marine Pharmacology in 2003-4: Antitumor and Cytotoxic Compounds. European Journal of Cancer 43:2241-2270, 2006.
8. Mayer, A.M.S. and M. T. Hamann. Marine pharmacology in 2001-2: Marine Compounds with Antibacterial, Anticoagulant, Antifungal, Anti-inflammatory, Antimalarial, Antiplatelet, Antiprotozoal, Antituberculosis, and Antiviral Activities;  affecting the Cardiovascular, Immune and Nervous Systems and other Miscellaneous Mechanisms of Action. Comparative Biochemistry and Physiology Part C  140(3-4):265-286, 2005.
7. Mayer, A.M.S. and K. R. Gustafson, Marine Pharmacology in 2001-2: Antitumor and Cytotoxic Compounds. European Journal of Cancer 40(18) 2676-2704, 2004.
6. Mayer, A.M.S. and M. T. Hamann. Marine pharmacology in 2000: Marine Compounds with Antibacterial, Anticoagulant, Antifungal, Anti-inflammatory, Antimalarial, Antiplatelet, Antiprotozoal, Antituberculosis, and Antiviral Activities;  affecting the Cardiovascular, Immune and Nervous Systems and other Miscellaneous Mechanisms of Action, Marine Biotechnology, 6: 37-52, 2004.
5. Mayer, A.M.S. and K. R. Gustafson, Marine Pharmacology in 2000: Antitumor and Cytotoxic Compounds. International Journal of Cancer 105: 291-299, 2003.
4. Mayer, A.M.S. and M. T. Hamann. Marine pharmacology in 1999: Marine Compounds with Antibacterial, Anticoagulant, Antifungal, Anthelmintic, Anti-inflammatory, Antiplatelet, Antiprotozoal, and Antiviral Activities; affecting the Cardiovascular, Endocrine, Immune and Nervous Systems and other Miscellaneous Mechanisms of Action, Comparative Biochemistry and Physiology, Part C 132/3: 315-339, 2002.
3. Mayer, A.M.S. and V.K.B. Lehmann. Marine Pharmacology in 1999: Antitumor and Cytotoxic Compounds. Anticancer Research 21: 2489-2500, 2001.
2. Alejandro M. S. Mayer and Virginia K. B. Lehmann, Marine Pharmacology in 1998: Marine Compounds with Antibacterial, Anticoagulant, Anti-inflammatory, Anthelmintic, Antiplatelet, Antiprotozoal, and Antiviral Activities; with actions on the Cardiovascular, Endocrine, Immune, and Nervous Systems; and other Miscellaneous Mechanisms of Action The Pharmacologist 42(2):62-69, 2000.
1. Alejandro M. S. Mayer, Marine Pharmacology in 1998: Antitumor and Cytotoxic Compounds. The Pharmacologist 41(4):159-164, 1999.

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