A.M.S. Mayer, Ph.D.
Professor of Pharmacology

Department of Pharmacology
Chicago College of Osteopathic Medicine
Midwestern University
555 31st Street
Downers Grove, IL 60515

 

Phone: (630) 515-6951
Fax: (630) 515-6295
E-mail: amayer@midwestern.edu

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MARINE PHARMACEUTICALS:
THE CLINICAL PIPELINE

As of August 2017, shown below are the marine-derived compounds which have been FDA-approved or are in Phase III, II or I of drug development and are part of the global marine pharmaceutical clinical pipeline since the review published by A.M.S. Mayer, K.B. Glaser, C. Cuevas, R.S. Jacobs, W. Kem, R.D. Little, J. M McIntosh, D.J. Newman, B.C. Potts and D. E. Shuster, Trends in Pharmacological Sciences, 31:255-265, 2010 ).

Please note: Currently all trials for PSMA-ADC, DEDN6526A, DMUC5754 have either been completed or are no longer active as listed in clinical trials.gov; however, these assets are still listed in company pipelines.


Clinical
Status
Compound
Name
Trademark
(FDA Approved Year)
Marine
Organism
Chemical
Class
Molecular
Target
US - Active Clinical
Trials
Europe - Active Clinical
Trials
Chinese - Active Clinical
Trials
Disease
Area
Company/
Institution
FDA-Approved Trabectedin
(ET-743)

Yondelis®
(2015)
Tunicate Alkaloid Minor groove of DNA [28+] [27+] None Cancer: Soft Tissue Sarcoma and Ovarian Cancer [Pharmamar]
Brentuximab vedotin
(SGN-35)
Adcetris®
(2011)
Mollusk/
cyanobacterium
ADC(MMAE) CD30 & microtubules [56+] [30+] None Cancer: Anaplastic large T-cell systemic maglinant lymphoma, Hodgkin's disease [Seattle Genetics]
Eribulin Mesylate (E7389) Halaven®
(2010)
Sponge Macrolide Microtubules [45+] [11+] None Cancer: Metastatic Breast Cancer [Eisai Inc.]
Omega-3-acid ethyl esters Lovaza®
(2004)
Fish Omega-3 fatty acids Trygliceride-synthesizing enzymes [18+] [1+] None Hypertriglyceridemia [GlaxoSmithKline]
Ziconotide Prialt®
(2004)
Cone snail Peptide N-Type
Ca channel
[1+] [1+] None Pain: Severe Chronic Pain [Jazz Pharmaceuticals]
Vidarabine
(Ara-A)
Vira-A®
(1976)
Sponge Nucleoside Viral DNA polymerase [139+] [2+] None Antiviral: Herpes Simplex Virus No Link
Cytarabine
(Ara-C)
Cytosar-U®
(1969)
Sponge Nucleoside DNA polymerase [293+] [137+] [11+] Cancer:Leukemia [Pfizer]
Phase III
Plinabulin
(NPI-2358)
NA Fungus Diketopiperazine Microtubules [6+] None None Cancer: Non-Small Cell Lung Cancer, Brain Tumor [BeyondSpring Pharmaceuticals]
Plitidepsin Aplidin® Tunicate Depsipeptide Rac1 & JNK activation [3+] [6+] None Cancer: Multiple Myeloma, Leukemia, Lymphoma [Pharmamar]
Squalamine Lactate
(OHR-102)
NA Dogfish Shark Aminosterol Growth factors of
neovascularization
[12+] [1+] None Neovascular Diseases: Macular Degeneration [Ohr Pharmaceutical Inc]
Tetrodotoxin Tectin® Pufferfish Guanidinium alkaloid Sodium Channel [1+] None None Pain: Chronic Pain [Wex Pharmaceutical Inc.]
Glembatumumab Vedotin (CDX-011) NA Mollusk/ cyanobacterium ADC (MMAE) GPNMB & microtubules [4+] [1+] None Cancer: Metastatic breast cancer, Metastatic melanoma, Triple negative breast cancer [Celldex Therapeutics]
Lurbinectedin (PM01183) NA Tunicate Alkaloid RNA Polymerase II [6+] [7+] None Cancer: Ovarian Cancer, Breast Cancer, SCLC [Pharmamar]
Phase II ABT-414
Depatuxizumab mafodotin
NA Mollusk/
cyanobacterium
ADC (MMAF) EGFR & microtubules [6+] [+2] None Cancer: Glioblastoma, Pediatric Brain Tumors [AbbVie]
GTS-21
(DMXBA)
NA Worm Alkaloid α7 nicotinic acetylcholine receptor [3+] None None Schizophrenia, Alzheimer Disease, Attention Deficit Hyperactivity Disorder, Endotoxemia, Sepsis, Vagal Activity No Link
Denintuzumab mafodotin
(SGN-CD19A)
NA Mollusk/
cyanobacterium
ADC (MMAF) CD19 & microtubules [2+] None None Cancer: relapsed/refractory and frontline DLBCL [Seattle Genetics]
AGS-16C3F NA Mollusk/
cyanobacterium
ADC (MMAF) ENPP3 & microtubules [2+] None None Cancer: Renal Cell Carcinoma [Agensys & Astellas Pharma]
Polatuzumab vedotin
(DCDS-4501A)
NA Mollusk/ cyanobacterium ADC (MMAE) CD79b & microtubules [2+] [1+] None Cancer: Non-Hodgkin lymphoma, Chronic lymphocytic leukemia, Lymphoma, B-Cell, lymphoma, Follicular [Genentech/Roche]
PM184 NA Sponge Polyketide Minor groove of DNA [1+] None None Cancer: Solid Tumors [Pharmamar]
Tisotumab Vedotin HuMax®-TF-ADC Mollusk/ cyanobacterium ADC (MMAE) Tissue Factor & microtubules [2+] None None Cancer: Ovary Cancer, Cervix Cancer, Endometrium Cancer, Bladder Cancer, Prostate Cancer (CRPC), Cancer of Head and Neck (SCCHN), Esophagus Cancer, Lung Cancer (NSCLC) [GenMab]
Enfortumab Vedotin
ASG-22ME
NA Mollusk/ cyanobacterium ADC (MMAE) Nectin-4 & microtubules [1+] None None Cancer: Tumors; Medical Oncology; Neoplasms; Metastatic Urothelial Cancer [Seattle Genetics]
Phase I GSK2857916 NA Mollusk/ cyanobacterium ADC (MMAF) BCMA [1+] None None Cancer: Multiple Myeloma [GlaxoSmithKline]
ABBV-085 NA Mollusk/ cyanobacterium ADC (MMAE) LRRC15 [1+] None None Cancer: Solid tumors [Abbvie]
ABBV-399 NA Mollusk/ cyanobacterium ADC (MMAE) c-Met [1+] None None Cancer: Solid tumors [Abbvie]
ABBV-221 NA Mollusk/ cyanobacterium ADC (MMAE) EGFR & microtubules [1+] None None Cancer: Solid tumors [Abbvie]
ASG-67E NA Mollusk/ cyanobacterium ADC (MMAE) CD37 & microtubules [2+] None None Cancer: Refractory Lymphoid Malignancy; Relapsed Lymphoid Malignancy [Agensys & Astellas Pharma]
ASG-15ME NA Mollusk/ cyanobacterium ADC (MMAE) SLITRK6 & microtubules [1+] None None Cancer: Metastatic Urothelial Cancer [Seattle Genetics]
Bryostatin NA Bryozoan Macrolide
Iactone
Protein kinase C [1+] None None Cancer: Melanoma, Renal Cell Cancer, Lymphoma, Pancreatic Cancer, Fallopian Tube Cancer, Gastric Cancer, Prostate Cancer, Kidney Cancer, Lung Cancer Neurotrope BioScience
Marizomib (Salinosporamide A; NPI-0052) NA Bacterium Beta-lactone-gamma lactam 20S proteasome [2+] None None Cancer: Non-Small Cell Lung Cancer, Pancreatic Cancer, Melanoma, Lymphoma, Multiple Myeloma [Triphase]
SGN-LIV1A NA Mollusk/
cyanobacterium
ADC (MMAE) LIV-1 & microtubules [1+] None None Cancer: Breast Cancer [Seattle Genetics]

 

Abbreviations:
ADC: Antibody Drug Conjugate;
Ara-A: 9-β-D-arabinofuranosyladenine
Ara-C: Cytosine Arabinoside
BCMA: B-cell Maturation Antigen
CD: Cluster of Differentiation;
c-Met: Tyrosine-Protein Kinase Met
DMXBA: 3-(2,4-Dimethoxybenzylidene)-Anabaseine
EGFR: Epidermal Growth Factor Receptor;
ENPP3: Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 3;
ET: Ecteinascidin
FDA: Food and Drug Administration;
GCC: Guanylyl Cyclase C;
GPNMB: Glycoprotein nonmetastatic B;
JNK: c-Jun N-terminal protein kinases;
LIV-1: Zinc transporter SLC39A6;
LY6E: Lymphocyte Antigen 6 Complex, Locus E
MMAE: Monomethylauristatin E;
MMAF: Monomethylauristatin F;
NA: Not Available;
NaPi2b: Sodium-Dependent Phosphate Transport Protein 2b;
PSMA: Prostate-Specific Membrane Antigen;
RAC1: Ras-related C3 botulinum toxin substrate 1;
SLITRK6: SLIT and NTRK-like protein 6;


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